With the world watching on, DeepMind’s AlphaFold 2 outperformed every other team at the 2020 biennial protein-structure prediction challenge, also known as CASP 14. This was a significant step forward in the history of molecular biology and medicine, but it would have not been made possible by prior efforts that finally culminated in the creation of AlphaFold 2. Let’s take a look at the history of protein folding before delving into the significance of this milestone in the field of molecular biology and beyond.