Metabolism is described as the series of chemical reactions required to sustain life, and when it comes to drug metabolism no one does it better than the cytochrome P450 family of enzymes. Understanding of key enzymes within this superfamily – such as CYP2D6, CYP2C9 and CYP3A4 – is an important part of drug design. Were you expecting The Incredibles? Sorry, not that super family, but still super nonetheless!
Pharmaceutical AbbVie’s Humira for the treatment of rheumatoid arthritis recorded sales of USD 16 billion in 2016 alone. As the pharmaceutical industry as a whole looks beyond small molecules to biologicals as therapeutics, there has been increasing interest and investment in research in the biotech sector. In this post a new approach to synthesizing small peptides is outlined, featuring an abstract written by a chemist doing active research in this area. Exciting Stuff!