Category: Structure-Based Design

For those with a basic knowledge of chemistry, we delve into the techniques researchers use to develop the next big ‘blockbuster’ compound.

ligand docked in protein crystal structure

Molecular Docking: Bioinformatics in Drug Discovery

Ever heard of the term bioinformatics? It’s an interdisciplinary field of science that combines different topics such as biology, computer science, mathematics and statistics. In a world where data is being generated at a faster rate than we can process,...

Cytochrome P450 Enzymes: Meet the (Super)family

Metabolism is described as the series of chemical reactions required to sustain life, and when it comes to drug metabolism no one does it better than the cytochrome P450 family of enzymes. Understanding of key enzymes within this superfamily –...

New Approaches to Peptide-Based Drugs

Pharmaceutical AbbVie’s Humira for the treatment of rheumatoid arthritis recorded sales of USD 16 billion in 2016 alone. As the pharmaceutical industry as a whole looks beyond small molecules to biologicals as therapeutics, there has been increasing interest and investment...