Category: Structure-Based Design

For those with a basic knowledge of chemistry, we delve into the techniques researchers use to develop the next big ‘blockbuster’ compound

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Strategies to Combat Antibiotic Resistance

Drug resistance is a common issue in drug discovery programs. After the long and expensive process of developing a drug, the last thing you want is to find that it doesn’t provide a therapeutic effect. Drug resistance is prevalent in...

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Medicinal Chemistry: Lead Modification and Optimization

Medicinal chemistry lays the foundation for the drug discovery process. A strong lead compound increases the chances of a pharmaceutical company developing a strong drug candidate, with better chances of success later on. Once a lead compound or ‘hit’ has...

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Medicinal Chemistry: Lead Discovery and Identification

Medicinal chemistry lays the foundation for the drug discovery process. A strong lead compound increases the chances of a pharmaceutical company developing a strong drug candidate, with better chances of success later on. However, choosing a compound from a library...

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Green Chemistry in Synthesis – The 12 Principles

In the 1990s, chemists began to better understand the impact of their activities on safety and sustainability, and took steps to address these issues. What followed was the adoption of certain practices that improved safety and reduced the environmental impact...